Mohoje, 26, was taken off early after being knocked out cold following a tackle on France's Louis Picamoles, who also went off not long after the incident.
South Africa coach Allister Coetzee said Mohoje, who won his 17th cap on Saturday, would have to “follow the concussion protocols” and take a week’s break from the game.
That rules him out of the final match of the French tour this coming Saturday at Ellis Park.
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Springbok centre Jesse Kriel was forced to sit out the second test after suffering a similar injury in South Africa’s 37-14 win in the opening match of the three test series in Pretoria last weekend.
(Reporting by Mark Gleeson; Editing by Toby Davis)
