After an even opening between two of the Championship's form sides, Wolves' former Sheffield United defender Conor Coady was dismissed after he pulled back Leon Clarke -- denying him a goalscoring chance in the 15th minute.
The hosts capitalised on their numerical advantage with Clarke scoring twice against his former club either side of a missed penalty from Wolves' Ruben Neves.
United have 21 points from 10 games -- two behind leaders Cardiff City and one ahead of Wolves and Leeds United.
United's rivals Sheffield Wednesday, in 14th, suffered a 1-0 defeat against struggling Birmingham City who climbed one place to 22nd thanks to Isaac Vassell's second-half goal.
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(Reporting By Tom Hayward; Editing by Toby Davis)
