State news agency SANA reported on Tuesday the airstrikes by the US-led coalition killed women and children.
SANA says the families were fleeing the city in boats across the Euphrates River ahead of an expected all-out attack by the Kurdish-led Syrian Democratic Forces.
The Britain-based Syrian Observatory for Human Rights said 21 people were killed in the Monday night air strikes. It said they were likely carried out by the US-led coalition.
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The air strikes have intensified in recent weeks as SDF fighters have reached the outskirts of the city.
