Nick Kyrgios' bid for a maiden grand slam title at the US Open will kick off against compatriot John Millman.
The No.14 seed, who lost the Cincinnati Masters final to Bulgaria's Grigor Dimitrov last week, was drawn to face the Queenslander in next week's opening round. The winner of the all-Australian showdown will eye a potential fourth round clash against five-time champion and third seed Roger Federer.
Both players find themselves on the same side of the draw as world No.1 Rafael Nadal, with a mouth-watering semi-final looming as a possibility. Federer and Nadal have never met at Flushing Meadows.
Nadal will face Serbia's Dusan Lajovic in the first round while Federer has Francis Tiafoe of the United States.
Maria Sharapova's grand slam return after a drug suspension comes against world No.2 Simona Halep in a spectacular clash to headline the women's opening round.
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"The American crowd is going to be very respectful of Maria and I would think she will get a warm reception coming back," Chris Evert, a winner of 18 majors during her career, said this week.
"Most people think that she has paid her dues and it's time to get back on the circuit."
Top-ranked Australian Daria Gavrilova gets her Open tilt under way against a qualifier, as do former world No.1s Venus Williams and Caroline Wozniacki in a women's draw where eight different players could leave New York atop the world rankings.
Ashleigh Barty, who has had a massive rise in the rankings in a season which also netted her first title, faces 21st seed Ana Konjuh. Rounding out the Australian women's contingent are Ajla Tomljanovic and Arina Rodionova, who will play Johanna Larsson and Richel Hogenkamp respectively.
Thanasi Kokkinakis will open his campaign against two-time quarter-finalist Janko Tipsarevic, while Bernard Tomic faces 19th seed Gilles Muller.
Jordan Thompson, who beat then-world No.1 Andy Murray in the lead-up to Wimbledon, is up against 13th seed Jack Sock.
Murray faces Tennys Sandgren as he chases a second US Open crown after his maiden grand slam triumph in 2012.
Spanish-born Sydney teenager Alex De Minaur has been handed a baptism of fire at Flushing Meadows and will face rising sixth seed Dominic Thiem in his first US Open match.
