Altidore, who had been included in the U.S. preliminary 40-man squad for the June 3-26 tournament, has a history of hamstring problems. In 2014 he suffered a hamstring pull in the first match of the World Cup and missed the rest of the tournament.
U.S. national team coach Jurgen Klinsmann must name his 23-man Copa America roster by Friday.
The Copa America, which will be held across 10 U.S. cities, will feature six teams from CONCACAF and all 10 teams from CONMEBOL.
(Reporting by Frank Pingue in Toronto; Editing by Peter Rutherford)
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