Gloves and condom maker Ansell is axing 100 products as part of a $US125 million ($A135.24 million) restructure of its global operations.
The changes will also result in 300 job losses, mostly from the closure of manufacturing sites in Malaysia and the United States.
The Australian headquarters of Ansell's sexual health division, which makes condoms and lubricants, will also be shifted to Brussels to be closer to growing markets, the company said.
Ansell will reorganise its business divisions, which make medical, industrial and sexual health products, simplifying its operations after recent business acquisitions.
It will dump 30 of its older brands by the end of 2014/15, meaning the end of 100 products, as it believes its core brands - Hyflex and Gammex - are strong enough to drive the company's growth.
Ansell said a reduction in value of some brands, redundancies and other restructuring measures will come at a pre-tax cost of $US124.7 million.
It expects to realise up to $US22 million ($A23.8 million) in annual savings as a result of the restructure from 2015/16.
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