Hourcade, who made seven changes to his side for last week's 39-22 loss to New Zealand, continued to tinker as the Pumas seek a first win of the competition.
Ramiro Moyano and Matias Orlando returned on the wing and at outside centre respectively, while Emiliano Boffelli moved from the wing to fullback in place of Joaquin Tuculet.
Martin Landajo got the start at scrumhalf ahead of Tomas Cubelli, who left the ACT Brumbies at the end of the Super Rugby season but was named on the bench for the match at their home Canberra Stadium.
In the only change to the pack, Hourcade plumped for a fourth number eight in as many tests by giving Tomas Lezana his first start at the back of the pack.
Juan Manuel Leguizamon, who was dropped after the 41-23 loss to South Africa in Salta, returns to the matchday squad on the bench with Benjamin Macome, who started against the All Blacks, omitted.
Winger Manuel Montero was also named among the replacements and will make his first appearance for the Pumas for more than a year if he gets on the pitch on Saturday.
Argentina opened their campaign with home-and-away losses to South Africa before last week's defeat at the hands of the world champions.
Team: 15-Emiliano Boffelli, 14-Matias Moroni, 13-Matias Orlando, 12-Jeronimo de la Fuente, 11-Ramiro Moyano, 10-Nicolas Sanchez, 9-Martin Landajo, 8-Tomas Lezana, 7-Javier Ortega Desio, 6-Pablo Matera, 5-Matias Alemanno, 4-Guido Petti, 3-Nahuel Tetaz Chaparro, 2-Agustin Creevy (captain), 1-Lucas Noguera.
Replacements: 16-Julian Montoya, 17-Santiago Garcia Botta, 18-Enrique Pieretto, 19-Marcos Kremer, 20-Juan Manuel Leguizamon, 21-Tomas Cubelli, 22-Santiago Gonzalez Iglesias, 23-Manuel Montero
(Reporting by Nick Mulvenney, editing by Ian Ransom)
