Barcelona's Lionel Messi scored twice in a 3-0 win over Las Palmas on Sunday in a La Liga match played without fans following clashes between police and voters in Catalonia over a banned independence referendum.
In the late game, Real Madrid earned their first home league victory of the season by beating Espanyol 2-0 with a goal in each half by midfielder Isco, while Valencia moved up to third in the standings after beating visitors Athletic Bilbao 3-2.
League leaders Barca tried to have their game postponed, but the request was turned down by La Liga and the Catalan club announced 25 minutes before kickoff that the game would be played behind closed doors.
Club president Josep Maria Bartomeu said the stadium was closed to show opposition to police violence against voters in Catalonia's independence referendum, which was banned by the national government, and not over safety concerns.
Spanish riot police on Sunday burst into polling stations across Catalonia to try to halt the referendum on a split from Spain and Catalan officials said more than 760 people were injured in the crackdown.
Barca's Sergio Busquets scored for the first time in the league in three seasons to give the hosts the lead in the 49th minute, leaping to head in a curling corner from Messi.
Argentine Messi then struck his 10th league goal of the season to double Barca's advantage in the 70th.
He barely celebrated the strike, adding to an atmosphere more akin to a training ground exercise than a league game.
Messi then latched onto a pass from fellow forward Luis Suarez to pounce again in the 77th, sealing Barca's seventh straight domestic league win this season and maintaining their 100 per cent start in La Liga and the Champions League.
"It was very strange, of course it's not normal, but today's events overshadowed the game," Busquets said on playing behind closed doors.
"Today was a special day, we had to focus on the sporting part, which wasn't very nice for us, and we were affected by everything as other things were on our minds," he added.
Real were missing Gareth Bale with a calf injury so Isco played in an advanced role behind Cristiano Ronaldo and made the most of a through ball from his Portuguese team mate to coolly fire under Pau Lopez and put Real ahead on the half-hour mark.
The champions were far from their best, but Isco later killed off the Catalans with his second goal.
Elsewhere, Real Sociedad and Real Betis played out a thrilling 4-4 draw, while new Villarreal coach Javi Calleja got off to a winning start at the Madrigal as they beat Eibar 3-0.
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