Bhutanese twins Nima and Dawa are on the home stretch to be reunited with their father after arriving five-months ago for separation surgery in Australia.
Twenty-month-olds Nima and Dawa will board another flight from Singapore to continue their 22-hour-journey to their Himalayan home with mum Bhumchu Zangmo.
The trio left Melbourne Airport on Wednesday night, after having life-changing surgery at the Royal Children's Hospital in Melbourne in November.
Their father and siblings are due to celebrate with family and friends on their return.
Ms Zangmo farewelled their Australian supporters and gave thanks for the support.
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"Nima, Dawa and Mum so happy, thank you," she said, before they checked into their Emirates flight.
"To the doctors, to the Children First Foundation ... I am very happy."
Foundation retreat manager Deb Pickering said the trio would be dearly missed but they'd stay in touch through social media and messaging apps.
"It's the best outcome of all. That's what she came here for and I think it has gone way over and above all expectations," Ms Pickering told reporters on behalf of Ms Zangmo.
"She is just so, so happy to be taking home two healthy, normal little girls."
The sisters will continue physiotherapy on their return home and are expected to hit all normal early childhood milestones.
The girls had been joined at the torso and shared a liver when they arrived in Australia.
The girls left the hospital weeks after surgery and recovered at the foundation's retreat.
