The Argentine became the first manager of the former European Cup finalists to win his first four games in charge in all competitions as Leeds made it three wins out of three in England's second-tier league.
They remain the only side with a perfect record after goals from Luke Ayling and Kemar Roofe earned them victory while Aston Villa's blemish-free start was ended with a 1-1 draw at Ipswich Town.
Unbeaten Middlesbrough, managed by Tony Pulis, are top of the table on 10 points from four games after winning 2-0 at Bristol City with first-half goals from Martin Braithwaite and Britt Assombalonga.
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Pulis's former club West Bromwich Albion delivered the most remarkable result of the day with their 7-1 crushing of Queens Park Rangers, who have suffered a pointless start to the season under former England manager Steve McClaren.
It was the Baggies' biggest win for three-and-a-half years with both Jay Rodriguez, with two penalties, and Matt Phillips scoring twice.
Frank Lampard, the former Chelsea and England midfielder, suffered a second straight Championship defeat in his new career as a manager as he watched his Derby County side lose 2-1 at Millwall.
In the evening game, Stoke City drew 2-2 at Preston, leaving their manager Gary Rowett still waiting for his first win in charge.
(Reporting by Ian Chadband,; Editing by Ed Osmond)
