Wales five-eighth Dan Biggar will miss his team's first three Six Nations matches due to a shoulder injury, the BBC reports.
Rhys Priestland is also ruled out of the majority of the tournament with a hamstring problem, leaving coach Warren Gatland without his two first-choice playmakers.
Biggar is likely miss the games against Scotland, England and Ireland, with Rhys Patchell, Owen Williams or Gareth Anscombe expected to wear the No.10 shirt.
Experienced Wales back-rowers Sam Warburton, Taulupe Faletau and Dan Lydiate - as well as centre Jonathan Davies - are also injured.
Wales start their Six Nations campaign against Scotland in Cardiff on February 3 before meeting defending champions England at Twickenham.
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