Bookmakers William Hill reckon the Portuguese coach an 8/11 bet, with Southampton's Mark Hughes and Cardiff City's Neil Warnock the second-favourites to part ways with their employers at 7/1.
"Mourinho was hovering near the even-money mark (where one pound sterling placed would earn a pound back in addition to the one-pound stake), however the draw against Valencia and the subsequent fallout has seen his odds of being the first manager to go plummet further," said William Hill spokesman Joe Crilly.
Zinedine Zidane is the 8/11 favourite to be the next Manchester United manager, with Antonio Conte at 8/1 and Arsene Wenger 10/1.
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Odds on first Premier League manager to leave:
8/11 Jose Mourinho (Manchester United)
7/1 Mark Hughes (Southampton)
7/1 Neil Warnock (Cardiff City)
10/1 Rafa Benitez (Newcastle United)
12/1 Claude Puel (Leicester City)
14/1 Sean Dyche (Burnley)
Next permanent Manchester United manager:
8/11 Zinedine Zidane
8/1 Antonio Conte
10/1 Arsene Wenger
14/1 Mauricio Pochettino
16/1 Joachim Loew
(Editing by Clare Fallon)
