Brisbane's forward depth will again be tested, with prop Payne Haas expected to miss up to a month with an ankle injury.
Scans on Monday are set to confirm Payne suffered a "mild high ankle strain" in the Broncos' controversial 22-20 NRL win over Canterbury on Thursday night.
"The injury is slated to keep him out for two to four weeks and he will also be monitored for any effects of concussion after coming from the field last night," the Broncos said in a statement.
Teammates Jack Bird (quad) and Alex Glenn (hamstring) have been cleared to play Manly on May 12.
But Haas' injury will further stretch Brisbane's already injury-hit forward stocks.
Lock Tevita Pangai, back-rower Jaydn Su'A, bench forward Joe Ofahengaue and prop Matt Lodge were enormous for Brisbane in their round-nine win over the Bulldogs at Suncorp Stadium.
They will need to back up against the Sea Eagles after Haas joined an injury list that includes Test stars Josh McGuire (ankle) and Matt Gillett (neck).
Coach Wayne Bennett hopes the depleted Brisbane pack takes confidence out of their out-muscling of the Bulldogs' giant forwards, including Aaron Woods and David Klemmer.
"To think we have got two Australian forwards not playing for us, we lost Payne pretty quickly and (still won) so it's pleasing," Bennett said.
"We were behind all night but they did not give up - they are qualities you want to see in your football team."
Backing up from last round's dream debut, Haas, 19, lasted just six minutes against Canterbury.
At first, Payne appeared concussed when he rose unsteadily from Klemmer's monster hit in the 56th minute and had to be escorted off the field.
But Haas was later seen leaving in a moon boot.
It could be worse for Brisbane.
Back-rower Glenn was cleared to play Manly despite leaving the field against Canterbury with hamstring tightness.
"Glenn was taken from the field with hamstring tightness to avoid any major damage to an injury he has suffered previously," the Broncos said.
"He was checked this morning and given the positive news from medical staff."
Halfback Bird was also given the green light after suffering a quad complaint when he slipped over and gifted a 65th-minute try to the Bulldogs.
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