Queensland Premier Annastacia Palaszczuk denies Bill Byrne's shock resignation is a trigger to call the state election and says there are some "outstanding" people who could take a tilt at his Rockhampton seat.
The premier confirmed on Saturday morning Mr Byrne was battling a serious medical condition and would not recontest the seat of Rockhampton at the next state election.
"Bill has been advised that his condition is life-threatening, and he will undertake more tests in Brisbane next week," she said in a statement.
"(He) will serve the remainder of this term in the parliament."
Later that day, she was asked if the surprise announcement could act as a trigger to send Queenslanders to the polls.
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"Not at all," Ms Palaszczuk replied.
She said the pair had held "numerous conversations" over preceding months and she "thoroughly" respected Mr Byrne's decision to quit cabinet.
"When I spoke to him ... I have never seen such alarm and shock in his voice," she told reporters.
But asked about who Labor may choose as a candidate in the Central Queensland seat - with Rockhampton Mayor Margaret Strelow reportedly on the party's wishlist - the premier simply said there were some "outstanding" options.
"I will be talking to the state secretary over the weekend about calling for the opening of nominations on Monday," she said.
The agriculture minister's shock resignation comes as speculation intensifies about the date of next state election, which may be called between now and May.
Earlier this week, the premier was forced to pour cold water on the mounting guesswork.
"The only people asking about the election, can I say, are journalists," Ms Palaszczuk said on Tuesday.
"Not one member of the public has come up to me and asked me about the election, so let's stop the speculation, let's everybody chill out and relax."
State Development Minister Dr Anthony Lynham will serve as acting minister for agriculture, fisheries and rural development.
Shadow treasurer Scott Emerson wished Mr Byrne a speedy recovery, but urged Ms Palaszczuk to "show some leadership and call the election date" as soon as possible.
