The Syrian Observatory for Human Rights said the toll was expected to rise because of the large number of people who suffered serious injuries, and that at least one child was among the dead.
Activists from the Syrian Revolution General Commission network said the blast took place on Monday in the market area of the Darkush, which is under rebel control.
A video posted by activists online showed the aftermath of the blast, with at least one car ablaze and the ground around it covering in smoking embers.
A second video showed residents carrying bodies on makeshift stretchers and extensive damage to buildings around the blast site.
Darkush, which lies on the Orontes river, is just a few kilometres from the border with Turkey.
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