Carbery was on debut when he replaced Johnny Sexton for the final 22 minutes of the historic 40-29 victory over world champions New Zealand in Chicago two years ago and this time he will start in the much-changed line-up named by coach Joe Schmidt on Thursday.
It will be a fourth start for the 23-year-old and a 13th test in all as he resumes a half-back pairing with former Leinster teammate, Canadian-born scrumhalf Luke McGrath, who will feature for Ireland for the first time in 2018.
It is a chance for both to stake a claim for a World Cup berth with the tournament in Japan under a year away and Sexton and Conor Murray the incumbents in the full test team.
Jordan Larmour is preferred at fullback for his first test start, with Andrew Conway and Jacob Stockdale on the wings, while New Zealand-born centre Bundee Aki is partnered with Garry Ringrose in what looks an explosive combination.
In the forward pack there is an all-Leinster back row as captain Rhys Ruddock scrums down with Josh van der Flier and Jack Conan, while the lock pairing sees Tadhg Beirne make a first start for Ireland alongside Quinn Roux.
Niall Scannell has been selected at hooker ahead of Sean Cronin, with props Jack McGrath and Andrew Porter either side of him.
There are two uncapped players on the bench in flyhalf Ross Byrne and centre Will Addison.
After Saturday’s test Ireland return home to face Argentina on Nov. 10, and then New Zealand and the United States on consecutive weekends after that.
Team: 15-Jordan Larmour, 14-Andrew Conway, 13-Garry Ringrose, 12-Bundee Aki, 11-Jacob Stockdale, 10-Joey Carbery, 9-Luke McGrath, 8-Jack Conan, 7-Josh van der Flier, 6-Rhys Ruddock (captain), 5-Quinn Roux, 4-Tadhg Beirne, 3-Andrew Porter, 2-Niall Scannell, 1-Jack McGrath
Replacements: 16-Sean Cronin, 17-Dave Kilcoyne, 18-Finlay Bealham, 19-Devin Toner, 20-Jordi Murphy, 21-John Cooney, 22-Ross Byrne, 23-Will Addison.
(Reporting By Nick Said; Editing by Richard Balmforth)
