UEFA rules governing European competition allow for ties to be rearranged if more than one club from a particular city is taking part, to prevent multiple games being held in the same city at the same time.
Chelsea, who won the Europa League in 2013, beat Malmo 5-1 on aggregate in the last round while Arsenal triumphed 3-1 over BATE Borisov over two legs.
Italy's Inter Milan are at Eintracht Frankfurt in their first leg, while Dinamo Zagreb host Portugal's Benfica, with Napoli taking on Austria's FC Salzburg.
Friday's draw was not protected by seeding, but teams from Russia and Ukraine were kept apart.
Russian side Krasnodar travel to Valencia for their first leg, while Zenit St Petersburg have also been drawn against Spanish opposition and host La Liga strugglers Villareal.
Sevilla, the third Spanish side still in this year's competition, have been drawn against Slavia Prague.
The first legs of the last-16 ties will be held on March 7 with the reverse fixtures scheduled for March 14.
(Reporting by Simon Jennings in Bengaluru; Editing by Christian Radnedge and Pritha Sarkar)
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