Isla, who has signed a three-year deal, has extensive experience of Serie A having moved to Udinese from Universidad Catolica in Chile before securing a contract with the 'Old Lady' of Italian football in 2012.
He was part of three title-winning campaigns at Juve but fell out of favour under Massimiliano Allegri and went on loan to Queens Park Rangers for the 2014-15 season although he could not prevent them being relegated from the Premier League.
Serie B champions Cagliari begin their Serie A campaign at Genoa on Aug. 21.
News that makes sense
Your trusted source for staying up-to-date with the world around you. Get free daily news updates and analysis, straight to your inbox.
(Reporting by Ed Dove; Editing by Ken Ferris/Rex Gowar)
