Two Britons and three Italians will appear in court on suspicion of involvement in smuggling 1.3 tonnes of cocaine into France.
A sixth suspect detained last week in connection with the record haul was released, judicial sources said on Tuesday, describing her as the partner of one of the two Britons.
A decision on whether the other five are formally charged is expected by late on Tuesday.
The drugs with an estimated street value of $US200 million euros ($A213.30 million) were concealed inside 30 suitcases that were placed on an Air France flight from the Venezuelan capital Caracas to Paris.
Venezuelan authorities have arrested an officer from the anti-drug unit of the Bolivarian National Guard and two National Guard sergeants on suspicion of involvement in the trafficking.
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According to police sources, the drugs arrived in France on September 11 but were not seized until the 20th, the investigators apparently having allowed time to see who was picking them up.
Part of the haul was seized at the airport and some on a truck headed towards Luxembourg - a route which suggests the end destination could have been the Netherlands or Britain.
British, Dutch and Spanish police were involved in the operation that led to the seizure, the biggest ever on French soil.
Venezuela has indicated that the traffickers must have had assistance from people working within Air France's operation at Caracas airport.
