Conte has urged his side to get the job done in Azerbaijan and avoid the tension of battling for progression during a busy schedule that sees the London outfit play 11 matches, after Wednesday's fixture, before the end of the year.
"We have to play the most important game of the season from the start until now," Conte told reporters.
"If we are able to win against Qarabag, we can go through to the next round of the Champions League and this is very important because this period from now until January is very busy, so it is very important to win the game.
"It won't be easy because in the last two games they drew twice against Atletico Madrid... it is very important to be focused, to work and to try to win the game."
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Chelsea are nine points behind leaders Manchester City in third position and travel to fifth-placed Liverpool in the league on Saturday.
(Reporting by Aditi Prakash in Bengaluru; Editing by John O'Brien)
