Qantas CEO Alan Joyce says passengers will need to provide proof they've had the COVID-19 vaccine in order to board the carrier's international flights.
Speaking to Channel Nine's A Current Affair program on Monday night, the CEO said it will be a "necessity" for international visitors coming in and out of Australia.
"We are looking at changing our terms and conditions to say for international travellers, we will ask people to have a vaccination before they can get on the aircraft," he said.
"Whether you need that domestically, we will have to see what will happen with Covid-19 and the market.
"But certainly for international visitors coming out and people leaving the country, we think that's a necessity."
The businessman's comments come after Prime Minister Scott Morrison made the government's vaccine stance known in August, saying a coronavirus vaccine will be "as mandatory as you can possibly make it" for Australians if a trial is successful.
At the time, Mr Morrison said every Australian could receive a free coronavirus vaccination early next year, if a promising trial proves successful.
Aiming for a 95 per cent vaccination rate, Mr Morrison said he was "hopeful but also naturally cautious" a drug being tested at Oxford University will be safe and effective.
The Oxford trial is being run in conjunction with British drug company AstraZeneca.
"We are not putting everything in the AstraZeneca basket but it is one of the most advanced and the most likely, based on the expert advice we have," Mr Morrison said.
"I'm advised we'll need about a 95 per cent vaccination rate across the country.
"That is the normal target range for when you're having a vaccination program and we'll be seeking to ensure that that is widely implemented."