A statement from the Confederation of African Football says the average temperature over the next month is expected to be between 35-38 degrees Celsius with an average humidity of 40-60%.
"This would give a high wet bulb globe temperature (WBGT) index reading above 32 degrees," it said.
The WBGT is the environmental measure that incorporates temperature, humidity, wind speed, sun angle and cloud cover.
"It is certain that most teams will be aware of this and will train accordingly," said CAF.
"At this level, FIFA recommends three minute rest-and-refreshing breaks in the 30th and 75th minutes.
"These breaks must require the provision of cold containers on wheels to put crushed ice, drinks for referees and small towels cold and wet to place around the neck for 26 people (four referees and 22 players)."
"It will also be necessary to prepare for any eventuality of emergencies," CAF added.
"It will be important to be able to diagnose and treat heat-related illnesses, if they occur on site."
Some matches at the tournament kick off at 1630 local time (1430 GMT), others at 1900 (1700 GMT) and 2200 (2000GMT) and then later, at the end of the group phase, at 1800 and 2100.
The timing of the Cup of Nations has also changed from January every two years to mid-year, although heat is only an issue at finals being played in the northern hemisphere.
Egypt were chosen above South Africa to be the hosts of 2019 final when Cameroon were stripped of the right to host the event late last year.
Had the tournament been played in South Africa over the next month, teams would have to deal with temperatures ranging from 24 degrees Celsius down to below freezing.
(Reporting by Mark Gleeson; Editing by Christian Radnedge)
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