"I will be taking the rest of the season day by day after having my appendix removed last night ... it's not ideal but I'll be alright," the 28-year-old, formerly Lizzie Armitstead, said on her Twitter page.
Deignan won the 2015 title in Virginia and was among the favourites to win it a second time in September.
The championships take place Sept. 17-24 in Bergen with the women's road race on Sept. 23.
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(Reporting by Martyn Herman; Editing by Susan Fenton)
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