The Western Bulldogs will be boosted by the returns of star duo Brooke Lochland and Isabel Huntington for their pivotal AFLW clash with Fremantle.
Lochland, last season's leading goalkicker, is back after breaking her leg in a training incident on the eve of the season, while Huntington returns from a pre-season knee injury.
The Bulldogs are bottom of Conference A with two wins from four rounds and need to beat third-placed Fremantle on Sunday at Fremantle Oval to stay in touch with the top two.
The Dockers have named Hayley Miller, Alica Janz, Leah Mascall and potential debutant Matilda Sergeant in an extended squad that will be trimmed by two players.
The top two teams in Conference B will kick off round five, first-placed Brisbane hosting Geelong on Saturday at Moreton Bay Sports Complex.
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The Lions welcome back skipper Leah Kaslar, a late exclusion last week, while the Cats have added Rene Caris and Kate Darby to replace suspended pair Maddie Boyd and Aasta O'Connor.
North Melbourne host Adelaide in a top-of-the-table clash in Conference A, the first-placed Roos regaining Courteney Munn from a calf injury.
The Crows have added first-year forward Chloe Scheer, but lose Courtney Cramey to a hamstring injury.
Carlton will have two debutants on Saturday when they host winless Collingwood at Ikon Park, with Charlotte Wilson and Emerson Woods in for their first games.
Darcy Guttridge will debut for the Pies who will regain Ash Brazill from a concussion.
GWS have included Jodie Hicks, Britt Perry and Erin McKinnon for their clash with Melbourne at Blacktown Oval, while Brooke Patterson, Maddy Guerin and Shelley Heath are in for the Demons.
