"Michy Batshuayi sustained an ankle injury in the Ruhr derby against FC Schalke 04 and will probably miss the remainder of the season," Dortmund said in a statement.
"However, there remains a chance that he could still feature for the Belgian national team at the World Cup in Russia this (European) summer."
Batshuayi has been in impressive form for Dortmund since securing a January loan move from Premier League side Chelsea until the end of the season, scoring nine goals in 14 appearances across all competitions.
He now faces a race against time to feature in Roberto Martinez's Belgium team, who begin their World Cup campaign against Panama on June 18.
"I didn't think it looked like the kind of injury that he would be back from quickly," Dortmund manager Peter Stoeger told the club's website https://www.bvb.de/eng following the injury.
"I hope, of course, that I'm mistaken. I can't yet say anything specific, other than the fact that he's in pain and will now be examined in more detail. Hopefully it's not as bad as it looks."
(Reporting by Hardik Vyas in Bengaluru; Editing by Christian Radnedge)
