Southampton probed for an equaliser but instead Watford substitute Janmaat dealt the killer blow, rifling the ball low into the corner from well outside the penalty area shortly after coming on as a second-half sub for James Ward-Prowse.
Southampton full back Cedric Soares forced Heurelho Gomes into a smart save late on with one of Southampton's few efforts on target, but Watford's defence held firm to secure their third clean sheet in four games.
(Reporting by Philip O'Connor,; Editing by Neville Dalton)
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