Mohammed Morsi was sentenced to death in June 2015 in connection with a mass jail break during the country's 2011 uprising.
The first president to be democratically elected after the 2011 revolt, Morsi was overthrown in mid-2013 by general-turned-president Abdel Fattah al-Sisi following mass protests against his rule.
The Court of Cassation ordered that Morsi be retried on the charges of participating in prison breaks and violence against policemen during the 2011 uprising which toppled longtime president Hosni Mubarak.
Five co-defendants, including the supreme guide of the now outlawed Muslim Brotherhood, Mohamed Badie, will also be retried.
Morsi has received lengthy jail sentences related to other charges, including two high-profile espionage cases.
Tuesday's court ruling means he no longer faces execution.
