Novak Djokovic will miss the rest of this season because of an injured right elbow.
That means Djokovic will pull out of the US Open and end his streak of participating in 51 consecutive grand slam tournaments.
The two-time US Open champion announced the news Wednesday, saying "this is the decision that had to be made at this moment."
Until now, Djokovic has never missed a major tournament since he entered his first, the 2005 Australian Open. That is the third-longest active run among men and seventh-longest in history.
In that time, the 30-year-old Serb has won 12 majors, including at Flushing Meadows in 2011 and 2015.
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"The remarkable series has come to an end," Djokovic said. "My body has its limits, and I have to respect that and be grateful for all that I have achieved so far."
He said that Andre Agassi, who recently began working with Djokovic on a part-time basis, will be his coach when he returns to the tour next year, starting with a tune-up tournament ahead of the Australian Open in January.
Djokovic's last match was on July 12, when he stopped playing during his Wimbledon quarterfinal against Tomas Berdych because of the elbow. Djokovic said that day he was in pain when he hit serves and forehands.
Since winning the 2016 French Open to complete a career grand slam and become the first man in nearly 50 years to win four consecutive major trophies, Djokovic's form has dipped. He has fallen from No.1 to No. 4 in the rankings and failed to defend any of those titles. He has made it past the quarter-finals at only one of the past five grand slams: last year's US Open, where he lost in the final to Stan Wawrinka.
Djokovic reached at least the semi-finals at Flushing Meadows in each of the past 10 years, including seven appearances in the final.
The US Open starts on August 28.
