Jonny Bairstow top-scored with 141 not out as England chased down their target of 289 in 38 overs to win the fifth and final one-day international against West Indies.
England finished on 1-294 on Friday after Joe Root smashed a six off Marlon Samuels to win the series 4-0 with the second match a no-result due to rain.
Bairstow, who also got a ton in the first match, hit 17 boundaries in his 114-ball innings. Jason Roy was the only English wicket to fall - trapped lbw for 96 by Miguel Cummins in the 22nd over - after an opening stand with Bairstow of 156.
"I'm pretty pleased," Bairstow told Sky Sports Cricket. "It's nice to finish a pretty long summer with some runs and head away this winter with a bit of confidence."
Root was 46 not out in 44 balls at Southampton with two fours and the winning six.
Earlier, Shai Hope struck 72 and Ashley Nurse added a late unbeaten 31 off 12 balls to help West Indies score 6-288 after England won the toss.
Chris Gayle hit five sixes - including four in a row across two overs - in a 29-ball 40 at the top of the innings to get the tourists off to a quick start.
Hope's knock was more measured, coming off 95 balls and including four fours and a six.
All eight of West Indies' batsmen got into double figures as they looked to avoid a series whitewash.
Jake Ball was smashed for 94 off his 10 overs, with spinners Adil Rashid (1-42) and Moeen Ali (1-36) the most economical of the England bowlers.
Share
