Jones, 24, was called into the England squad for the first time by coach Eddie Jones and had been in contention to make his test debut.
“It’s a big blow and I really feel for Sam because he has worked his socks off for Wasps and deservedly got his call-up to England," Wasps director of rugby Dai Young told the club website.
“My biggest disappointment is for Sam as he’s been playing so well and I’m sure would have made a good impression in the England camp."
England, unbeaten this year, host South Africa at Twickenham on Nov. 12 before meeting Fiji, Argentina and Australia.
(Reporting by Ed Osmond; Editing by Toby Davis)
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