Bristol Bears flanker Poppy Leitch will replace Marlie Packer, who will be rested after she picked up a shoulder injury in their opener against Ireland, while the back line remains unchanged.
"Vickii and Abbie bring considerable experience to the forward pack while Poppy is a great addition having played consistently well in the Tyrrells Premier 15s and for the National Academy side in the autumn," Middleton said in a statement.
"We will rest Marlie this weekend with the aim of having her back later in the Championship."
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France powered past Wales 52-3 in their opener while England beat Ireland 51-7, with the weekend's clash billed as a potential title decider.
France narrowly beat England 18-17 en route to a Grand Slam last year.
(Reporting by Rohith Nair in Bengaluru; Editing by Toby Davis)
