The initial contract with NBC begins at the start of the 2016-17 season in September.
"This new agreement with NBC Sports Group is an historic milestone for us. It takes the Aviva Premiership Rugby brand to a bigger audience than we have ever had in the U.S.," Premiership Rugby chief executive Mark McCafferty said in a statement on Tuesday.
The Saracens v London Irish game will be the first English Premiership rugby match to be played overseas.
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(Reporting by Shravanth Vijayakumar in Bengaluru, editing by Ed Osmond)
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