Vakatawa, who scored a hat-trick of tries in Saturday's 52-8 victory against Samoa, and his Clermont team mate Nakaitaci will start alongside the impressive pair of centres of Remi Lamerat and Wesley Fofana, another Clermont player.
Nakaitaci has scored five tries from eight appearances with leaders Clermont in the French Top 14 this season.
Noves made five changes to the team who thrashed Samoa, with Nakaitaci coming in for Huget and Jean-Marc Doussain taking over at flyhalf after Francois Trinh-Duc was ruled out of the series with a broken forearm.
In the third row, Charles Ollivon replaces Loann Goujon who is out injured while second rower Sebastien Vahamahina is taking Julien Le Devedec's place and prop Cyril Baille is getting his first start in place of the injured Jefferson Poirot.
For all their firepower at the back, however, France will need to put on a huge defensive display if they are to beat the Wallabies for the second time in a row after prevailing 29-26 in 2014.
"We suffered for the first 4-5 minutes against Samoa but we must know that it's going to be the case for 80 minutes against Australia," Noves told a news conference.
"So defence will be very important. We haven't seen many weak points in their team. They are impressive in the way they keep the ball."
Australia started their November series with a 32-8 win against Wales before beating Scotland 23-22 last weekend.
They will then take on Ireland and England while France will end their series against New Zealand.
Team:
15-Scott Spedding - 14-Noa Nakaitaci, 13-Remi Lamerat, 12-Wesley Fofana, 11-Virimi Vakatawa - 10-Jean-Marc Doussain, 9-Maxime Machenaud - 8-Louis Picamoles, 7-Kevin Gourdon, 6-Charles Ollivon - 5-Yoann Maestri, 4-Sebastien Vahaamahina - 3-Uini Atonio, 2-Guilhem Guirado (captain), 1-Cyril Baille
Replacements: 16-Camille Chat, 17-Xavier Chiocci, 18-Rabah Slimani, 19-Julien Le Devedec, 20-Damien Chouly, 21-Baptiste Serin, 22-Camille Lopez, 23-Gael Fickou
(Reporting by Julien Pretot; Editing by Amlan Chakraborty)
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