First Clinton grandchild thrills Bill and Hillary

Chelsea Clinton has thrilled her parents Bill and Hillary with the birth of their first grandchild, Charlotte.

Chelsea Clinton, husband Marc Mezvinsky, and their daughter Charlotte

Chelsea Clinton has announced she's given birth to her first child, daughter Charlotte. (AAP)

Chelsea Clinton has announced she has given birth to her first child, daughter Charlotte, thrilling first-time grandparents Bill and Hillary.

"Marc and I are full of love, awe and gratitude as we celebrate the birth of our daughter, Charlotte Clinton Mezvinsky," Chelsea Clinton wrote on Facebook.

The message was also posted on Twitter, after the baby's birth on Friday, and immediately retweeted by the proud grandparents.

The former first daughter, 34, frequently tipped to follow her parents into politics, left her position as NBC special correspondent in August to focus on her pregnancy and the birth of her daughter.

Clinton announced in mid-April at an event with her mother in Manhattan that she and investment banker husband Marc Mezvinsky were expecting their first child.

Former president Bill Clinton and former Secretary of State Hillary Clinton have made no secret of their joy at becoming grandparents.

On Saturday, they announced that they were "blessed, grateful and so happy."

They said the "beautiful" Charlotte had been born on Friday evening.

"We are thrilled to be with our daughter and her husband as they welcome their daughter into the world," they said in a statement.

"Chelsea is well and glowing. Marc is bursting with pride. Charlotte's life is off to a good start."

The baby had been so highly anticipated that even President Barack Obama cracked jokes this week while attending a Clinton foundation event in New York, offering his motorcade if needed to speed through the Big Apple's gridlock to give birth.

"I was just discussing with president Clinton -- if Chelsea begins delivery while I am speaking, she has my motorcade and will be able to navigate traffic," Obama said, drawing chuckles at the Clinton Global Initiative meeting.

Bill spoke of high hopes for his future grandchildren earlier this week.

"I want them to get up every day and look at the world with wonder and reverence. I want them to respect everyone they meet, whatever their background. I want them to be aware of all the people that make their world and not just the people that they are introduced to," Clinton told ABC News.

"I want them to really love being alive," he said, adding "and when they grow up, I want them to believe they have certain obligations to people who don't have all the opportunities they'll have and to the larger society."

Hillary is widely anticipated to launch a second bid to become the first woman president of the United States in 2016.

Bill Clinton served as the 42nd US president, from January 1993 to January 2001.


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