Northampton flanker Teimana Harrison comes into the back row in place of openside James Haskell, who was unable to recover from a foot injury, the team said in a statement on Thursday.
New Zealand-born 23-year-old Harrison, previously described as a 'street-fighter' by Jones, will line up for only his second cap after his debut against Wales last month.
"Teimana has trained well throughout the tour and deserves his spot," Australian Jones said.
"He's an excellent defender and his robustness will be important to us at the start of the game."
After England sealed the series 2-0 with a 23-7 victory in Melbourne, Jones spoke of injecting fresh legs at Sydney Football Stadium while resting some weary players.
But he has left the side otherwise unchanged for a dead rubber he likened to a "World Cup final".
There was some doubt that winger Jack Nowell might not recover from a head-knock but he cleared concussion protocols to leave Harlequins' Jack Clifford warming the bench again.
"Jack Clifford is unlucky to miss out, but will finish the game for us," added Jones. "We've treated this week like a dress rehearsal for the World Cup because that what we're always building towards.
"To win a World Cup you have to win three big games in a row -- we've won two so this third game is the most important game we'll play all year.
"It will be a good indication of where we are as a team."
Team:
15-Mike Brown, 14-Anthony Watson, 13-Jonathan Joseph, 12-Owen Farrell, 11-Jack Nowell, 10-George Ford, 9-Ben Youngs 8- Billy Vunipola, 7-Teimana Harrison, 6-Chris Robshaw, 5-George Kruis, 4-Maro Itoje, 3-Dan Cole, 2-Dylan Hartley, 1-Mako Vunipola
Replacements: 16-Jamie George, 17-Matt Mullan, 18-Paul Hill, 19-Joe Launchbury, 20-Courtney Lawes, 21-Jack Clifford,
22-Danny Care, 23-Elliot Daly
(Reporting by Ian Ransom in Melbourne; Editing by Martyn Herman/Sudipto Ganguly)
