Dylan Hartley is back to lead England in their final Six Nations game against Ireland, but George Ford, Danny Care and prop Dan Cole are dropped as Eddie Jones takes radical action following two successive defeats.
Hartley missed last week's defeat by France but has recovered from a calf strain.
Jones has brought in Richard Wigglesworth at scrumhalf and moved Owen Farrell to No.10 for Saturday's match with Ben Te'o and Jonathan Joseph in the centres.
There is also a new-look backrow with James Haskell starting at openside flanker, Sam Simmonds at number eight and Chris Robshaw moved back to blindside.
Anthony Watson retains the fullback shirt, with Mike Brown again on the bench.
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Prop Kyle Sinckler is rewarded for his impressive cameo with a starting berth, with Cole dropped to the bench while George Kruis starts in the second row ahead of Joe Launchbury.
Following losses in Scotland and France, defending champions England are trying to avoid three successive Six Nations defeats for the first time since 2006.
If they do lose on Saturday - handing Ireland their third grand slam in the process - they could finish outright fifth in the standings, their worst performance for 35 years.
England team to play Ireland.
Anthony Watson, Jonny May, Jonathan Joseph, Ben Te'o, Elliot Daly, Owen Farrell, Richard Wigglesworth; Mako Vunipola, Dylan Hartley, Kyle Sinckler, Maro Itoje, George Kruis, Chris Robshaw, James Haskell, Sam Simmonds.
Replacements: Jamie George, Joe Marler, Dan Cole, Joe Launchbury, Don Armand, Danny Care, George Ford, Mike Brown.
