Flanker Fabien Sanconnie will make his debut and Brice Dulin will return at fullback in the France team for the Six Nations match against Italy in Rome.
The 22-year-old Sanconnie, who plays for Brive in the Top 14 league, replaces Bernard Le Roux, while Dulin will make his first start of the tournament.
In a boost for coach Guy Noves, experienced fly-half Francois Trinh-Duc will return to the squad after recovering from a broken arm and take his place on the bench.
Trinh-Duc, who has 56 Test caps, is likely to come on for Camille Lopez at some point during the match.
France needed a last-gasp penalty to beat Italy 23-21 at home last year but routed the Italians 29-0 away in 2015.
Italy have lost their three matches so far in 2017, against Wales, Ireland and England, and are in last place.
France are fifth, beating Scotland at home but losing at England and Ireland.
FRANCE (15-1):
Brice Dulin, Noa Nakaitaci, Remi Lamerat, Gael Fickou, Virimi Vakatawa, Camille Lopez, Baptiste Serin; Louis Picamoles, Kevin Gourdon, Fabien Sanconnie, Yoann Maestri, Julien Le Devedec, Rabah Slimani, Guilhem Guirado (capt), Cyril Baille.
Res: Christopher Tolofua, Uini Atonio, Eddy Ben Arous, Paul Jedrasiak, Bernard Le Roux, Antoine Dupont, Francois Trinh-Duc, Yoann Huget.
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