Guillermo Garcia-Lopez beat second-seeded Spanish countryman Pablo Carreno Busta 7-6 (7-5) 1-6 7-6 (8-6) on Thursday to reach the Argentina Open quarter-finals.
Garcia-Lopez will face Argentina's Federico Delbonis, a 7-6 (7-5) 7-6 (8-6) winner over Portugal's Gastao Elias in the clay-court event.
France's Gael Monfils and Argentina's Leonardo Mayer set up another quarter-final.
Monfils beat Dusan Lajovic of Serbia 6-4 6-3 and Mayer stopped fourth-seeded Fabio Fognini of Italy 6-3 6-3.
The other quarter-finals were set on Wednesday, with top-seeded Dominic Thiem of Austria set to face Guido Pella of Argentina, and Slovenia's Aljaz Bedene to play Argentina's Diego Schwartzman.
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