Loew said the trio were nursing minor injuries and would need a few days to recover with the world champions taking on Azerbaijan in a World Cup qualifier in Baku on Sunday.
"Those who will not play tomorrow are Ozil, who has some muscle problems. Julian Draxler has the same injury, an upper thigh muscle," Loew said on Tuesday.
"Mario Gomez has an adductor muscle injury and may need a few days."
Gomez's absence is especially disappointing with the striker having netted in his last three Bundesliga games for VfL Wolfsburg and appearing to have rediscovered his form.
Germany are already without injured keeper Manuel Neuer, with Loew having called up Kevin Trapp as a replacement.
(Reporting by Karolos Grohmann; Editing by Ken Ferris)
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