Her 20-under 268 total matched the tournament record low set by Cristie Kerr in 2015, when Lee finished runner-up.
"It’s been a long time to be winner of the tournament,” Lee told reporters via a translator after clinching her third LPGA victory at the age of 26.
“So I (was) kind of nervous before I started. But I tried to focus and then it gave me a good result.”
Fellow South Korean Ryu So-yeon and American Austin Ernst tied for second on 14-under in the final tune-up for players before the first major of the season, the ANA Inspiration starting on Thursday.
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(Reporting by Andrew Both in Cary, North Carolina; Editing by Ian Ransom)
