A group of 22 refugees are on their way from Nauru to the United States where they will be resettled.
The 21 men and one woman will fly from Nauru airport to Los Angeles on Sunday afternoon, refugee advocate Ian Rintoul says.
They are among some 130 refugees who will leave the island this month under Australia's resettlement deal with the US.
The group includes Afghanis, Pakistanis and stateless Rohingya refugees, and they are the second group to depart Nauru.
But Mr Rintoul, spokesman for the Refugee Action Coalition, says the resettlement process is flawed because Iranians are being excluded, sparking protests at the island.
He also said one Rohingya man, who is leaving on Sunday, had family in Australia and had initially declined to travel to the US.
"I don't know anyone there," he told the Refugee Action Coalition, according to a statement from the group on Sunday.
The US resettlement deal was struck between former president Barack Obama and Prime Minister Malcolm Turnbull, providing a path out of detention for refugees offshore, including at Manus Island and Nauru.
