"We are going to suffer because they are taller and stronger than us. In some areas they will be better than us," Guardiola told a news conference on Friday.
"We prepare with a lot of respect they have done incredible in the competition, beating Leicester and Boro. What they do, they do really well.
"They are ready, it's not the first time they've played away in a cup competition in a lower division. We will take this very seriously, I am sure about that."
City's multi-million pound squad, used to the pristine surfaces of their own Etihad Stadium and other Premier League venues, are set for a unique challenge at Rodney Parade, a ground which Newport share with two Welsh rugby union clubs.
Guardiola accepts it will be difficult to execute their typical pass-and-move football but said his title-winning squad is capable of finding solutions.
"I have seen vintage games here in the 70s and 80s and all the pitches were bad. Now, most of the pitches are perfect," he said.
"That's the big difference in England now, you can play in different ways, before it wasn't possible.
"Now the pitch you will see tomorrow (how it is) and we have to adapt, we have to play longer or quicker, we have to see. You don't win anything complaining. They are the owners and we have to adapt."
(Reporting by Hardik Vyas in Bengaluru; Editing by Christian Radnedge)
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