Guardiola said the Germany international had not suffered a recurrence of the cruciate ligament injury that cut short his first season in England.
"It was a tough situation for him but I think Ilkay will be okay," Guardiola told British media.
"He has a small issue with his knee, but not like before and I don't think it will be anything serious."
City, who are joint top of the Premier League with rivals Manchester United after five games, host basement side Crystal Palace on Saturday.
News that makes sense
Your trusted source for staying up-to-date with the world around you. Get free daily news updates and analysis, straight to your inbox.
(Writing by Simon Jennings in Bengaluru, editing by Nick Mulvenney)
