Australian
Hewitt, who turns 30 next week, won the first set but slumped to a 4-6 6-3 6-4 loss to world No.8 Roddick, who is seeking his third Memphis crown and 30th career title.
Roddick has now won the last six clashes between the pair, with Hewitt's last triumph in their 11-year rivalry coming in the 2005 Indian Wells semi-finals.
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