Commenting ahead of a polo match in aid of his Sentebale charity, Harry said he continued to support the world's commitment to ending the AIDS epidemic by 2030.
Harry hopes to raise a STG 1 million ($A1.7 million) from the event being staged in Singapore for his organisation's work with HIV positive children in Lesotho and Botswana as well as other projects helping vulnerable youngsters.
Writing in the official program for the Sentebale Polo Cup, with his charity co-founder Prince Seeiso of Lesotho, the prince said: "In the past year we have expanded operations into Botswana, addressing the pressing needs of the country with the world's third-highest HIV prevalence.
"We will continue to support the global commitment to ending the AIDS epidemic by 2030.
"We believe that we cannot beat HIV without giving children and adolescents the voice they deserve.
"It is our ambition to change the tide of this epidemic by ensuring more young people know their status, access treatment and are empowered to tackle stigma and play their part in bringing the AIDS epidemic to an end."
Inroads have been made in tackling the Aids epidemic among adults and the under-fives in Africa but it is still the biggest killer of the continent's adolescents.
They face problems with accessing treatment, as clinics are sometimes only open during school hours, stigmatisation is still prevalent and the language used by adults helping them can be offputting.
