Italy coach Conor O'Shea has retained only five players from the team who lost to Ireland for the Test against Georgia in Florence.
Backs Mattia Bellini, Michele Campagnaro, who captained the side in Chicago, and Luca Sperandio kept their places along with scrumhalf Tito Tebaldi and Braam Steyn, who moves from flanker to No.8.
Italy were hammered 54-7 by the Irish, albeit with a weakened team, and need to bounce back against Georgia on Saturday before facing Australia in Padua next week.
Italy's ability to properly compete in the Six Nations is under perennial question, with Georgia often cited as a team with better credentials to play in Europe's elite competition.
"We all know the importance of this match," O'Shea told a news conference on Thursday.
News that makes sense
Your trusted source for staying up-to-date with the world around you. Get free daily news updates and analysis, straight to your inbox.
"The team has recovered well from the trip to the US and we are ready to face Georgia. It will be a very physical match. We want to show our maximum level for 80 minutes," he said.
Italy are without injured captain Sergio Parisse, who could return next week against the Wallabies.
Italy team:
Luca Sperandio, Tommaso Benvenuti, Michele Campagnaro, Tommaso Castello, Mattia Bellini, Tommaso Allan, Tito Tebaldi, Braam Steyn, Jake Polledri, Sebastian Negri, Dean Budd, Alessandro Zanni, Simone Ferrari, Leonardo Ghiraldini (capt), Andrea Lovotti.
Reps: Luca Bigi, Cherif Traore, Tiziano Pasquali, Marco Fuser, Johan Meyer, Guglielmo Palazzani, Carlo Canna, Luca Morisi.
