Blake Bortles has passed for 377 yards and four touchdowns as the Jacksonville Jaguars avenged last season's loss in the AFC Championship game with a 31-20 victory over the visiting New England Patriots in the NFL.
Patriots quarterback Tom Brady threw for 234 yards and two touchdown passes but Rob Gronkowski was well shackled by the Jaguars defence.
Dak Prescott threw a 64-yard touchdown pass to Tavon Austin on the third play of the game and Dallas Cowboys sacked Eli Manning six times in a 20-13 victory over the New York Giants in the Sunday night game.
Antonio Brown broke an NFL catching record but could not stop his Pittsburgh Steelers side from a 42-37 home defeat to the Kansas City Chiefs.
The wide receiver produced a nine-reception performance to become the quickest player to reach 750 catches in his 117th regular season match.
The Chiefs were led by six touchdown passes from quarterback Patrick Mahomes.
Tampa Bay Buccaneers overcame a later charge from Super Bowl winners Philadelphia Eagles to earn a 27-21 win to start the season with successive victories.
Buccaneers quarterback Ryan Fitzpatrick produced his second four-touchdown display in as many weeks.
Cleveland Browns blew their chance of victory for the first time since December 13, 2016 after they let a nine-point lead slip in a 21-18 defeat at the New Orleans Saints.
Daniel Carlson missed two field goals in overtime for the Minnesota Vikings as they played out an entertaining 29-29 draw with the Green Bay Packers at Lambeau Field.
Matt Ryan came out on top in the battle between the star quarterbacks as he ran in for one touchdown and threw two more as the Atlanta Falcons beat Cam Newton's Carolina Panthers 31-24.
Brandon McManus kicked a 36-yard field goal with six seconds to play as the Denver Broncos rallied in the fourth quarter to snatch a 20-19 win over the visiting Oakland Raiders.
Matt Breida rushed for a career-best 138 yards and Robbie Gould set a franchise record for most consecutive made field goals to propel the San Francisco 49ers to a 30-27 home victory over the Detroit Lions.
Andrew Luck threw two touchdown passes but was also intercepted twice as the Indianapolis Colts ran out 21-9 winners against the Washington Redskins.
Tennessee Titans almost let a 14-point lead slip as they squeezed past the Houston Texans in a 20-17 triumph thanks to two Ryan Succop field goals in the final quarter.
Los Angeles Rams rolled to a 34-0 victory over the visiting Arizona Cardinals with Todd Gurley rushing for three touchdowns.
Miami Dolphins defeated the New York Jets 20-12 while the Buffalo Bills remain without a win after a 31-20 loss to the Los Angeles Chargers.
