Karzai summoned his security chiefs for an emergency meeting early Wednesday to brief him about Tuesday's suicide attack near a Shiite shrine in Kabul on Shiite Muslims' holiest day of Ashura, Aimal Faizi told AFP.
Later in the day, Karzai will visit a hospital in the city where dozens of people injured in the bombing are being treated, the spokesman added.
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Karzai was in Germany when Tuesday's massive attack took place, the day after the Bonn conference on the future of Afghanistan.
But he cancelled a planned onward trip to Britain after the attack.
It was the deadliest strike on the capital in three years and Karzai said it was the first time insurgents had targeted such an important religious day.
The Taliban, the main militant group responsible for most attacks in Afghanistan, have denied responsibility for the bombing.
At a press conference with German Chancellor Angela Merkel earlier Tuesday in Berlin, Karzai said the bombings were the first "terrorist" attacks of their kind on the Shiite holy day of Ashura.
The attacks occurred just a day after an international conference in Bonn on the future of Afghanistan after NATO troops pull out at the end of 2014, and raised fears of possible sectarian tensions.
