Lock George Kruis is back in England's lineup against Argentina on Saturday after recovering from ankle surgery which forced him to miss the wins over South Africa and Fiji this month.
Also recalled are flanker Tom Wood, winger Jonny May, and fullback Mike Brown after Fiji was beaten 58-15 last weekend.
Kruis was an integral part of England's Six Nations Grand Slam and series sweep in Australia, and his return to fitness was timely after lock Joe Launchbury was suspended on Monday for two weeks for kicking a Fijian.
Wood replaces Northampton teammate Teimana Harrison at openside flanker, where he played against the Springboks.
May, on the left wing in the South Africa match, displaces Semesa Rokoduguni on the right wing.
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Brown was in for Alex Goode.
"Selection was interesting this week but it shows how competitive and how much depth we are developing," coach Eddie Jones said.
England: Mike Brown, Jonny May, Jonathan Joseph, Owen Farrell, Elliot Daly, George Ford, Ben Youngs; Billy Vunipola, Tom Wood, Chris Robshaw, George Kruis, Courtney Lawes, Dan Cole, Dylan Hartley (captain), Mako Vunipola. Reserves: Jamie George, Joe Marler, Kyle Sinckler, Charlie Ewels, Teimana Harrison, Danny Care, Ben Te'o, Henry Slade.
