"Having consulted with my team and medical experts it is deemed too risky for me to step out and potentially play five sets on clay especially as I have not played a singles match in nearly two months.
"I've worked hard to be ready and desperately wanted to play Roland Garros, which is very special to me but I literally ran out of time."
Kyrgios was scheduled to take on compatriot Bernard Tomic in the opening round on Monday.
(Reporting by Shrivathsa Sridhar in Bengaluru; Editing by Christian Radnedge)
